Superoxide dismutase [Cu-Zn] (P00441)

Uniprot ID P00441
Protein Name Superoxide dismutase [Cu-Zn]
Gene Name SOD1
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.823
Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
GO - Molecular function
  • chaperone binding : IPI:UniProtKB
  • copper ion binding : IDA:UniProtKB
  • identical protein binding : IPI:IntAct
  • protein homodimerization activity : NAS:UniProtKB
  • protein phosphatase 2B binding : IDA:UniProtKB
  • Rac GTPase binding : IDA:UniProtKB
  • superoxide dismutase activity : IDA:UniProtKB
  • zinc ion binding : IDA:UniProtKB
GO - Biological process
  • activation of MAPK activity : ISS:UniProtKB
  • anterograde axonal transport : ISS:BHF-UCL
  • auditory receptor cell stereocilium organization : ISS:UniProtKB
  • cell aging : IMP:UniProtKB
  • cellular iron ion homeostasis : ISS:UniProtKB
  • cellular response to ATP : IEA:Ensembl
  • cellular response to cadmium ion : IEA:Ensembl
  • cellular response to oxidative stress : TAS:Reactome
  • cellular response to potassium ion : IEA:Ensembl
  • embryo implantation : ISS:UniProtKB
  • glutathione metabolic process : ISS:UniProtKB
  • heart contraction : IDA:UniProtKB
  • hydrogen peroxide biosynthetic process : IDA:UniProtKB
  • interleukin-12-mediated signaling pathway : TAS:Reactome
  • locomotory behavior : ISS:UniProtKB
  • muscle cell cellular homeostasis : ISS:UniProtKB
  • myeloid cell homeostasis : ISS:UniProtKB
  • negative regulation of cholesterol biosynthetic process : IDA:UniProtKB
  • negative regulation of neuron apoptotic process : ISS:UniProtKB
  • neurofilament cytoskeleton organization : ISS:UniProtKB
  • ovarian follicle development : ISS:UniProtKB
  • peripheral nervous system myelin maintenance : ISS:UniProtKB
  • placenta development : NAS:UniProtKB
  • platelet degranulation : TAS:Reactome
  • positive regulation of apoptotic process : IC:UniProtKB
  • positive regulation of catalytic activity : IDA:UniProtKB
  • positive regulation of cytokine production : IDA:UniProtKB
  • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway : IMP:BHF-UCL
  • positive regulation of superoxide anion generation : IDA:UniProtKB
  • reactive oxygen species metabolic process : IDA:UniProtKB
  • regulation of blood pressure : ISS:UniProtKB
  • regulation of GTPase activity : IDA:UniProtKB
  • regulation of mitochondrial membrane potential : IMP:UniProtKB
  • regulation of multicellular organism growth : ISS:UniProtKB
  • regulation of organ growth : NAS:UniProtKB
  • regulation of protein kinase activity : IDA:UniProtKB
  • regulation of T cell differentiation in thymus : NAS:UniProtKB
  • relaxation of vascular smooth muscle : ISS:UniProtKB
  • removal of superoxide radicals : ISS:UniProtKB
  • response to amphetamine : IEA:Ensembl
  • response to antipsychotic drug : IEA:Ensembl
  • response to axon injury : ISS:UniProtKB
  • response to carbon monoxide : IEA:Ensembl
  • response to copper ion : IEA:Ensembl
  • response to drug : ISS:UniProtKB
  • response to ethanol : ISS:UniProtKB
  • response to heat : ISS:UniProtKB
  • response to hydrogen peroxide : ISS:UniProtKB
  • response to organic substance : IDA:UniProtKB
  • response to superoxide : IDA:UniProtKB
  • retina homeostasis : ISS:UniProtKB
  • retrograde axonal transport : ISS:BHF-UCL
  • sensory perception of sound : ISS:UniProtKB
  • spermatogenesis : ISS:UniProtKB
  • superoxide anion generation : IEA:Ensembl
  • superoxide metabolic process : IDA:BHF-UCL
  • thymus development : NAS:UniProtKB
  • transmission of nerve impulse : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.