Glutathione reductase, mitochondrial (P00390)

Uniprot ID P00390
Protein Name Glutathione reductase, mitochondrial
Gene Name GSR
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.573
Function Maintains high levels of reduced glutathione in the cytosol.
GO - Molecular function
  • electron transfer activity : TAS:UniProtKB
  • flavin adenine dinucleotide binding : IBA:GO_Central
  • glutathione-disulfide reductase activity : IBA:GO_Central
  • NADP binding : IEA:InterPro
GO - Biological process
  • cell redox homeostasis : IBA:GO_Central
  • cellular response to oxidative stress : IBA:GO_Central
  • glutathione metabolic process : IBA:GO_Central
  • nucleobase-containing small molecule interconversion : TAS:Reactome
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.