NADH-cytochrome b5 reductase 3 (P00387)

Uniprot ID P00387
Protein Name NADH-cytochrome b5 reductase 3
Gene Name CYB5R3
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.752
Function Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
GO - Molecular function
  • ADP binding : IEA:Ensembl
  • AMP binding : IEA:Ensembl
  • cytochrome-b5 reductase activity, acting on NAD(P)H : TAS:Reactome
  • FAD binding : IDA:UniProtKB
  • flavin adenine dinucleotide binding : IEA:Ensembl
  • NAD binding : IEA:Ensembl
  • oxidoreductase activity : IBA:GO_Central
GO - Biological process
  • blood circulation : TAS:ProtInc
  • cholesterol biosynthetic process : IEA:UniProtKB-KW
  • L-ascorbic acid metabolic process : TAS:Reactome
  • neutrophil degranulation : TAS:Reactome
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.