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P00375

Dihydrofolate reductase (P00375)

Uniprot ID P00375
Protein Name Dihydrofolate reductase
Gene Name Dhfr
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) N Secretome P(b) 0.591
Function Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (PubMed:25980602). Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (PubMed:25980602). Binds its own mRNA. .
GO - Molecular function
  • dihydrofolate reductase activity : IDA:UniProtKB
  • dihydrofolic acid binding : ISO:MGI
  • drug binding : ISS:UniProtKB
  • folic acid binding : ISO:MGI
  • methotrexate binding : ISO:MGI
  • mRNA binding : ISS:UniProtKB
  • NADP binding : ISO:MGI
  • NADPH binding : ISO:MGI
  • sequence-specific mRNA binding : ISO:MGI
  • translation repressor activity, mRNA regulatory element binding : ISO:MGI
GO - Biological process
  • axon regeneration : ISO:MGI
  • dihydrofolate metabolic process : ISO:MGI
  • folic acid metabolic process : ISO:MGI
  • negative regulation of translation : ISO:MGI
  • one-carbon metabolic process : IEA:UniProtKB-KW
  • oxidation-reduction process : ISO:MGI
  • positive regulation of nitric-oxide synthase activity : IMP:BHF-UCL
  • regulation of removal of superoxide radicals : IMP:BHF-UCL
  • response to methotrexate : ISO:MGI
  • response to nicotine : IEA:Ensembl
  • tetrahydrobiopterin biosynthetic process : IMP:BHF-UCL
  • tetrahydrofolate biosynthetic process : ISO:MGI
  • tetrahydrofolate metabolic process : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.