| Signal peptide(a) |
Y |
Secretome P(b) |
0.0 |
| Function |
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). . |
| GO - Molecular function |
- coreceptor activity involved in Wnt signaling pathway : ISO:MGI
- frizzled binding : ISO:MGI
- identical protein binding : ISO:MGI
- kinase inhibitor activity : ISO:MGI
- low-density lipoprotein particle receptor activity : ISO:MGI
- protein homodimerization activity : ISO:MGI
- signaling receptor binding : ISO:MGI
- toxin transmembrane transporter activity : IMP:BHF-UCL
- Wnt-activated receptor activity : IBA:GO_Central
- Wnt-protein binding : IPI:MGI
|
| GO - Biological process |
- anterior/posterior pattern specification : IMP:MGI
- axis elongation : IMP:MGI
- axis elongation involved in somitogenesis : IGI:MGI
- bone remodeling : IGI:MGI
- branching involved in mammary gland duct morphogenesis : IMP:MGI
- canonical Wnt signaling pathway : IMP:MGI
- canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development : IMP:MGI
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation : IMP:MGI
- cell migration involved in gastrulation : IGI:MGI
- cell-cell adhesion : ISO:MGI
- cellular response to cholesterol : ISO:MGI
- cerebellum morphogenesis : IMP:MGI
- cerebral cortex cell migration : IMP:MGI
- cerebral cortex development : IMP:MGI
- chemical synaptic transmission : ISO:MGI
- convergent extension : IGI:MGI
- dopaminergic neuron differentiation : IMP:MGI
- dorsal/ventral axis specification : IMP:MGI
- embryonic camera-type eye morphogenesis : IMP:MGI
- embryonic digit morphogenesis : IMP:MGI
- embryonic forelimb morphogenesis : IMP:MGI
- embryonic hindlimb morphogenesis : IMP:MGI
- embryonic limb morphogenesis : IGI:MGI
- embryonic pattern specification : IMP:MGI
- embryonic retina morphogenesis in camera-type eye : IMP:MGI
- external genitalia morphogenesis : IMP:MGI
- face morphogenesis : IMP:MGI
- forebrain development : IMP:MGI
- forebrain generation of neurons : IMP:MGI
- forebrain radial glial cell differentiation : IGI:MGI
- formation of radial glial scaffolds : IGI:MGI
- gastrulation with mouth forming second : IGI:MGI
- generation of neurons : IMP:MGI
- heart looping : IGI:MGI
- limb morphogenesis : IMP:MGI
- mammary gland duct morphogenesis : IGI:MGI
- mammary placode formation : IMP:MGI
- midbrain development : IMP:MGI
- midbrain-hindbrain boundary development : IMP:MGI
- negative regulation of epithelial cell proliferation : IMP:MGI
- negative regulation of fat cell differentiation : IMP:MGI
- negative regulation of non-canonical Wnt signaling pathway : IGI:MGI
- negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis : IGI:MGI
- negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis : IGI:MGI
- negative regulation of planar cell polarity pathway involved in neural tube closure : IGI:MGI
- negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis : IGI:MGI
- negative regulation of planar cell polarity pathway involved in pericardium morphogenesis : IGI:MGI
- negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis : IGI:MGI
- negative regulation of protein kinase activity : ISO:MGI
- negative regulation of protein phosphorylation : ISO:MGI
- negative regulation of protein serine/threonine kinase activity : ISO:MGI
- negative regulation of smooth muscle cell apoptotic process : ISO:MGI
- negative regulation of Wnt signaling pathway : IGI:MGI
- neural crest cell differentiation : ISO:MGI
- neural crest formation : ISO:MGI
- neural tube closure : IMP:MGI
- neural tube development : IGI:MGI
- odontogenesis of dentin-containing tooth : IMP:MGI
- pericardium morphogenesis : IGI:MGI
- positive regulation of apoptotic process : IMP:MGI
- positive regulation of bone resorption : IMP:MGI
- positive regulation of canonical Wnt signaling pathway : ISO:MGI
- positive regulation of cell cycle : ISO:MGI
- positive regulation of cytosolic calcium ion concentration : ISO:MGI
- positive regulation of DNA binding transcription factor activity : IMP:BHF-UCL
- positive regulation of mesenchymal cell proliferation : IMP:MGI
- positive regulation of neuron projection development : IGI:ARUK-UCL
- positive regulation of ossification : IMP:MGI
- positive regulation of transcription by RNA polymerase II : ISO:MGI
- positive regulation of transcription, DNA-templated : IDA:BHF-UCL
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification : ISO:MGI
- post-anal tail morphogenesis : IMP:MGI
- primitive streak formation : IGI:MGI
- protein localization to plasma membrane : ISO:MGI
- receptor-mediated endocytosis involved in cholesterol transport : IMP:MGI
- regulation of canonical Wnt signaling pathway : ISO:MGI
- regulation of cell development : IMP:MGI
- regulation of cell proliferation : IMP:MGI
- regulation of transcription, DNA-templated : ISO:MGI
- response to folic acid : IMP:MGI
- retina morphogenesis in camera-type eye : IMP:MGI
- roof of mouth development : IMP:MGI
- skeletal system morphogenesis : IMP:MGI
- somitogenesis : IGI:MGI
- thalamus development : IMP:MGI
- trachea cartilage morphogenesis : IGI:MGI
- Wnt signaling pathway : IGI:MGI
- Wnt signaling pathway involved in dorsal/ventral axis specification : ISO:MGI
- Wnt signaling pathway involved in forebrain neuroblast division : IMP:MGI
- Wnt signaling pathway involved in somitogenesis : IMP:MGI
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