WD repeat-containing protein 1 (O88342)

Uniprot ID O88342
Protein Name WD repeat-containing protein 1
Gene Name Wdr1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.638
Function Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). Enhances cofilin-mediated actin severing (PubMed:25915128). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (By similarity). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage (PubMed:24840128). Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding (PubMed:17515402). Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (PubMed:25915128). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (By similarity). .
GO - Molecular function
  • actin binding : ISO:MGI
  • actin filament binding : ISS:UniProtKB
GO - Biological process
  • actin cytoskeleton organization : IMP:MGI
  • actin filament fragmentation : IMP:UniProtKB
  • apical junction assembly : ISO:MGI
  • cortical cytoskeleton organization : IMP:UniProtKB
  • establishment of planar polarity of follicular epithelium : IMP:UniProtKB
  • maintenance of epithelial cell apical/basal polarity : ISO:MGI
  • neutrophil mediated immunity : IMP:UniProtKB
  • neutrophil migration : IMP:UniProtKB
  • platelet formation : IMP:UniProtKB
  • positive regulation of actin filament depolymerization : IGI:MGI
  • regulation of actin filament depolymerization : ISO:MGI
  • regulation of cell shape : IMP:UniProtKB
  • regulation of oligodendrocyte differentiation : ISO:MGI
  • regulation of ventricular cardiac muscle cell membrane repolarization : IMP:MGI
  • sarcomere organization : IMP:MGI
  • sensory perception of sound : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.