Cathepsin S (O70370)

Uniprot ID O70370
Protein Name Cathepsin S
Gene Name Ctss
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.588
Function Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
GO - Molecular function
  • collagen binding : ISO:MGI
  • cysteine-type endopeptidase activity : EXP:Reactome
  • cysteine-type peptidase activity : ISO:MGI
  • fibronectin binding : ISO:MGI
  • laminin binding : ISO:MGI
  • peptidase activity : IDA:MGI
  • proteoglycan binding : ISO:MGI
GO - Biological process
  • antigen processing and presentation : IBA:GO_Central
  • antigen processing and presentation of peptide antigen : ISO:MGI
  • basement membrane disassembly : IMP:BHF-UCL
  • bone resorption : ISO:MGI
  • collagen catabolic process : ISO:MGI
  • immune response : IBA:GO_Central
  • positive regulation of cation channel activity : IDA:CACAO
  • positive regulation of inflammatory response : IGI:MGI
  • protein processing : ISO:MGI
  • proteolysis : IDA:MGI
  • proteolysis involved in cellular protein catabolic process : IMP:BHF-UCL
  • regulation of sensory perception of pain : ISO:MGI
  • response to acidic pH : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.