E3 ubiquitin-protein ligase LNX (O70263)

Uniprot ID O70263
Protein Name E3 ubiquitin-protein ligase LNX
Gene Name Lnx1
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b)
Function E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. .Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. {ECO:0000269|PubMed:9535908}.
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • PDZ domain binding : IDA:MGI
  • ubiquitin-protein transferase activity : IDA:MGI
GO - Biological process
  • protein homooligomerization : IDA:MGI
  • ubiquitin-dependent protein catabolic process : IDA:MGI
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.