Signal peptide(a) |
N |
Secretome P(b) |
|
Function |
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. .Isoform 2 provides an endocytic scaffold for IGSF5/JAM4. {ECO:0000269|PubMed:9535908}. |
GO - Molecular function |
- metal ion binding : IEA:UniProtKB-KW
- PDZ domain binding : IDA:MGI
- ubiquitin-protein transferase activity : IDA:MGI
|
GO - Biological process |
- protein homooligomerization : IDA:MGI
- ubiquitin-dependent protein catabolic process : IDA:MGI
|