| Signal peptide(a) |
Y |
Secretome P(b) |
|
| Function |
Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. . |
| GO - Molecular function |
- CCR chemokine receptor binding : IBA:GO_Central
- chemoattractant activity : ISO:RGD
- chemokine activity : IDA:RGD
- CX3C chemokine receptor binding : ISS:UniProtKB
- CXCR1 chemokine receptor binding : ISO:RGD
- integrin binding : ISS:UniProtKB
|
| GO - Biological process |
- aging : IEP:RGD
- angiogenesis involved in wound healing : ISO:RGD
- autocrine signaling : IGI:ARUK-UCL
- cell adhesion : ISO:RGD
- cell chemotaxis : ISO:RGD
- cell-cell adhesion : IDA:ARUK-UCL
- cellular response to interferon-gamma : IBA:GO_Central
- cellular response to interleukin-1 : IBA:GO_Central
- cellular response to tumor necrosis factor : IBA:GO_Central
- chemokine-mediated signaling pathway : ISO:RGD
- chemotaxis : IDA:RGD
- cytokine-mediated signaling pathway : ISO:RGD
- eosinophil chemotaxis : IBA:GO_Central
- G protein-coupled receptor signaling pathway : IGI:ARUK-UCL
- inflammatory response : IBA:GO_Central
- inhibitory postsynaptic potential : IMP:RGD
- integrin activation : ISS:UniProtKB
- leukocyte adhesive activation : IEA:InterPro
- leukocyte migration involved in inflammatory response : ISS:UniProtKB
- lymphocyte chemotaxis : ISO:RGD
- macrophage chemotaxis : ISO:RGD
- microglial cell activation : IDA:ARUK-UCL
- microglial cell proliferation : ISO:RGD
- monocyte chemotaxis : IBA:GO_Central
- negative regulation of apoptotic process : ISO:RGD
- negative regulation of apoptotic signaling pathway : ISO:RGD
- negative regulation of cell migration : ISO:RGD
- negative regulation of cytokine secretion : IMP:RGD
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : ISO:RGD
- negative regulation of glutamate receptor signaling pathway : IDA:ARUK-UCL
- negative regulation of hippocampal neuron apoptotic process : ISO:RGD
- negative regulation of interleukin-1 alpha production : IDA:ARUK-UCL
- negative regulation of microglial cell activation : IDA:ARUK-UCL
- negative regulation of tumor necrosis factor secretion : ISO:RGD
- negative regulation of vasoconstriction : IDA:RGD
- neuron cellular homeostasis : IDA:ARUK-UCL
- neutrophil chemotaxis : ISO:RGD
- platelet activation : IMP:RGD
- positive chemotaxis : ISO:RGD
- positive regulation of actin filament bundle assembly : ISO:RGD
- positive regulation of angiogenesis : ISO:RGD
- positive regulation of calcium-independent cell-cell adhesion : ISO:RGD
- positive regulation of cell adhesion : IDA:RGD
- positive regulation of cell migration : IDA:RGD
- positive regulation of cell population proliferation : ISO:RGD
- positive regulation of ERK1 and ERK2 cascade : IBA:GO_Central
- positive regulation of GTPase activity : IBA:GO_Central
- positive regulation of I-kappaB kinase/NF-kappaB signaling : IGI:ARUK-UCL
- positive regulation of I-kappaB phosphorylation : ISO:RGD
- positive regulation of inflammatory response : ISO:RGD
- positive regulation of macrophage chemotaxis : IMP:RGD
- positive regulation of MAPK cascade : ISO:RGD
- positive regulation of microglial cell migration : ISO:RGD
- positive regulation of neuroblast proliferation : IDA:RGD
- positive regulation of neuron projection development : IDA:ParkinsonsUK-UCL
- positive regulation of NF-kappaB transcription factor activity : ISO:RGD
- positive regulation of protein kinase B signaling : IMP:ARUK-UCL
- positive regulation of release of sequestered calcium ion into cytosol : ISO:RGD
- positive regulation of smooth muscle cell proliferation : IDA:ARUK-UCL
- positive regulation of transcription by RNA polymerase II : IDA:ARUK-UCL
- positive regulation of transforming growth factor beta1 production : ISO:RGD
- regulation of lipopolysaccharide-mediated signaling pathway : ISO:RGD
- response to hypoxia : IEP:RGD
- response to ischemia : IGI:ARUK-UCL
- wound healing : ISO:RGD
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