Coatomer subunit beta' (O55029)

Uniprot ID O55029
Protein Name Coatomer subunit beta'
Gene Name Copb2
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.516
Function The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). .This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner.
GO - Molecular function
  • protein kinase C binding : ISO:MGI
  • structural molecule activity : IEA:InterPro
GO - Biological process
  • ER to Golgi vesicle-mediated transport : IBA:GO_Central
  • intra-Golgi vesicle-mediated transport : ISO:MGI
  • intracellular protein transport : IBA:GO_Central
  • retrograde vesicle-mediated transport, Golgi to ER : IBA:GO_Central
  • toxin transport : IMP:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.