| Signal peptide(a) |
Y |
Secretome P(b) |
0.325 |
| Function |
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. . |
| GO - Molecular function |
- enzyme binding : ISO:RGD
- G protein-coupled neurotensin receptor activity : TAS:RGD
- nerve growth factor binding : ISO:RGD
- nerve growth factor receptor activity : ISO:RGD
- neurotensin receptor activity, non-G protein-coupled : ISO:RGD
|
| GO - Biological process |
- endocytosis : ISS:UniProtKB
- endosome to lysosome transport : ISO:RGD
- endosome transport via multivesicular body sorting pathway : ISO:RGD
- extrinsic apoptotic signaling pathway via death domain receptors : ISO:RGD
- G protein-coupled receptor signaling pathway : ISO:RGD
- glucose import : ISO:RGD
- Golgi to endosome transport : ISO:RGD
- intracellular protein transport : NAS:RGD
- multicellular organism development : IEA:UniProtKB-KW
- myotube differentiation : ISO:RGD
- negative regulation of fat cell differentiation : ISO:RGD
- negative regulation of lipoprotein lipase activity : ISO:RGD
- neuropeptide signaling pathway : ISO:RGD
- neurotrophin TRK receptor signaling pathway : ISO:RGD
- ossification : IEA:UniProtKB-KW
- plasma membrane to endosome transport : ISO:RGD
- positive regulation of epithelial cell apoptotic process : IMP:RGD
- post-Golgi vesicle-mediated transport : IBA:GO_Central
- regulation of gene expression : ISO:RGD
- response to insulin : ISO:RGD
- vesicle organization : ISO:RGD
|