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O35593

26S proteasome non-ATPase regulatory subunit 14 (O35593)

Uniprot ID O35593
Protein Name 26S proteasome non-ATPase regulatory subunit 14
Gene Name Psmd14
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.863
Function Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. .
GO - Molecular function
  • endopeptidase activator activity : ISO:MGI
  • endopeptidase activity : ISS:MGI
  • Lys63-specific deubiquitinase activity : IEA:InterPro
  • metal ion binding : IEA:UniProtKB-KW
  • metallopeptidase activity : IEA:UniProtKB-KW
  • proteasome binding : ISO:MGI
  • thiol-dependent ubiquitinyl hydrolase activity : ISS:UniProtKB
GO - Biological process
  • double-strand break repair via homologous recombination : ISS:UniProtKB
  • double-strand break repair via nonhomologous end joining : ISS:UniProtKB
  • protein K63-linked deubiquitination : ISS:UniProtKB
  • regulation of proteasomal protein catabolic process : ISO:MGI
  • response to ethanol : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.