| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit (By similarity). . |
| GO - Molecular function |
- androgen receptor binding : ISO:MGI
- chromatin binding : IDA:MGI
- disordered domain specific binding : ISO:MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific : IDA:MGI
- estrogen receptor binding : ISO:MGI
- histone acetyltransferase activity : ISO:MGI
- nuclear hormone receptor binding : ISO:MGI
- nuclear receptor binding : ISO:MGI
- nuclear receptor transcription coactivator activity : ISO:MGI
- peroxisome proliferator activated receptor binding : ISO:MGI
- protein heterodimerization activity : ISO:MGI
- protein N-terminus binding : ISO:MGI
- protein-containing complex binding : ISO:MGI
- RNA polymerase II complex binding : IDA:UniProtKB
- RNA polymerase II regulatory region DNA binding : ISO:MGI
- RNA polymerase II transcription regulator recruiting activity : IDA:MGI
- transcription coactivator activity : IDA:UniProtKB
|
| GO - Biological process |
- cell dedifferentiation : IMP:UniProtKB
- cellular response to estradiol stimulus : ISO:MGI
- cellular response to hormone stimulus : IBA:GO_Central
- developmental growth : IMP:MGI
- labyrinthine layer morphogenesis : IGI:MGI
- mammary gland branching involved in thelarche : IMP:MGI
- multicellular organism growth : IMP:MGI
- negative regulation of apoptotic process : ISO:MGI
- negative regulation of stem cell differentiation : IMP:MGI
- positive regulation of cell growth : ISO:MGI
- positive regulation of DNA-binding transcription factor activity : ISO:MGI
- positive regulation of gene expression : IMP:MGI
- positive regulation of intracellular estrogen receptor signaling pathway : ISO:MGI
- positive regulation of intracellular steroid hormone receptor signaling pathway : ISO:MGI
- positive regulation of keratinocyte differentiation : ISO:MGI
- positive regulation of stem cell population maintenance : IMP:UniProtKB
- positive regulation of transcription by RNA polymerase II : ISO:MGI
- regulation of RNA biosynthetic process : ISO:MGI
- regulation of stem cell division : IMP:UniProtKB
- regulation of stem cell population maintenance : IMP:MGI
- regulation of stem cell proliferation : IMP:MGI
- vagina development : IMP:MGI
|