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O08784

Treacle protein (O08784)

Uniprot ID O08784
Protein Name Treacle protein
Gene Name Tcof1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) N Secretome P(b) 0.101
Function Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. .
GO - Molecular function
  • protein heterodimerization activity : ISO:MGI
  • RNA polymerase I core binding : ISS:UniProtKB
  • scaffold protein binding : ISO:MGI
GO - Biological process
  • neural crest cell development : ISS:UniProtKB
  • neural crest formation : ISS:UniProtKB
  • nucleolar large rRNA transcription by RNA polymerase I : IMP:MGI
  • regulation of translation : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.