| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). . |
| GO - Molecular function |
- dihydrolipoyl dehydrogenase activity : IMP:MGI
- electron transfer activity : IEA:InterPro
- flavin adenine dinucleotide binding : ISO:MGI
- lipoamide binding : ISO:MGI
- NAD binding : ISO:MGI
- pyruvate dehydrogenase (NAD+) activity : IEA:Ensembl
|
| GO - Biological process |
- 2-oxoglutarate metabolic process : ISO:MGI
- acetyl-CoA biosynthetic process from pyruvate : ISO:MGI
- aging : IEA:Ensembl
- cell redox homeostasis : IEA:InterPro
- dihydrolipoamide metabolic process : ISO:MGI
- gastrulation : IMP:MGI
- histone succinylation : ISS:UniProtKB
- lipoate metabolic process : ISO:MGI
- mitochondrial acetyl-CoA biosynthetic process from pyruvate : ISO:MGI
- mitochondrial electron transport, NADH to ubiquinone : IMP:MGI
- proteolysis : IDA:MGI
- regulation of membrane potential : IMP:MGI
- sperm capacitation : IDA:MGI
|