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O08553

Dihydropyrimidinase-related protein 2 (O08553)

Uniprot ID O08553
Protein Name Dihydropyrimidinase-related protein 2
Gene Name Dpysl2
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.612
Function Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. .
GO - Molecular function
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds : IEA:InterPro
  • identical protein binding : ISO:MGI
  • microtubule binding : IEA:InterPro
  • protein kinase binding : IPI:UniProtKB
GO - Biological process
  • axon guidance : IEA:InterPro
  • cytoskeleton organization : IDA:UniProtKB
  • endocytosis : ISS:UniProtKB
  • olfactory bulb development : IEA:Ensembl
  • positive regulation of glutamate secretion : ISO:MGI
  • regulation of axon extension : IEA:InterPro
  • regulation of neuron differentiation : ISO:MGI
  • regulation of neuron projection development : IGI:MGI
  • response to amphetamine : IEA:Ensembl
  • response to cocaine : IEA:Ensembl
  • spinal cord development : IEA:Ensembl
  • synaptic vesicle transport : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.