| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957). Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Activates the transcription of CYP2C38 (By similarity). . |
| GO - Molecular function |
- chromatin binding : ISS:BHF-UCL
- DNA binding : IDA:UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific : IEA:Ensembl
- DNA-binding transcription factor activity : IDA:UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific : ISA:NTNU_SB
- nuclear receptor activity : IBA:GO_Central
- phospholipid binding : IDA:UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding : ISS:BHF-UCL
- sequence-specific DNA binding : IDA:UniProtKB
- steroid hormone receptor activity : IEA:InterPro
- transcription regulatory region DNA binding : IDA:BHF-UCL
- transcription regulatory region sequence-specific DNA binding : IBA:GO_Central
- zinc ion binding : IEA:InterPro
|
| GO - Biological process |
- bile acid metabolic process : IEA:Ensembl
- calcineurin-mediated signaling : IEA:Ensembl
- cellular response to leukemia inhibitory factor : IEA:Ensembl
- cholesterol homeostasis : IEA:Ensembl
- embryo development ending in birth or egg hatching : TAS:UniProtKB
- epithelial cell differentiation : IEA:Ensembl
- homeostatic process : NAS:UniProtKB
- hormone-mediated signaling pathway : IBA:GO_Central
- pancreas morphogenesis : IEA:Ensembl
- positive regulation of transcription by RNA polymerase II : ISS:BHF-UCL
- positive regulation of transcription, DNA-templated : IDA:BHF-UCL
- positive regulation of viral genome replication : IDA:BHF-UCL
- regulation of cell population proliferation : IEA:Ensembl
- regulation of transcription, DNA-templated : IDA:UniProtKB
- tissue development : IBA:GO_Central
- transcription initiation from RNA polymerase II promoter : TAS:Reactome
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