Thrombospondin 1 (M3YA63)

Uniprot ID	M3YA63
Protein Name	Thrombospondin 1
Gene Name	THBS1
Species	Mustela putorius furo (European domestic ferret) (Mustela furo)

Signal peptide^(a)	Y	Secretome P^(b)	0.445
Function
GO - Molecular function	calcium ion binding : IEA:UniProtKB-UniRule collagen V binding : IEA:Ensembl fibrinogen binding : IEA:Ensembl fibroblast growth factor binding : IEA:Ensembl fibronectin binding : IEA:Ensembl heparin binding : IEA:Ensembl integrin binding : IEA:Ensembl laminin binding : IEA:Ensembl low-density lipoprotein particle binding : IEA:Ensembl phosphatidylserine binding : IEA:Ensembl
GO - Biological process	activation of MAPK activity : IEA:Ensembl cell adhesion : IEA:InterPro cell cycle arrest : IEA:Ensembl cell migration : IEA:Ensembl chronic inflammatory response : IEA:Ensembl engulfment of apoptotic cell : IEA:Ensembl extracellular matrix organization : IEA:InterPro immune response : IEA:Ensembl negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II : IEA:Ensembl negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis : IEA:Ensembl negative regulation of cell migration involved in sprouting angiogenesis : IEA:Ensembl negative regulation of cell-matrix adhesion : IEA:Ensembl negative regulation of cGMP-mediated signaling : IEA:Ensembl negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : IEA:Ensembl negative regulation of dendritic cell antigen processing and presentation : IEA:Ensembl negative regulation of endothelial cell chemotaxis : IEA:Ensembl negative regulation of fibrinolysis : IEA:Ensembl negative regulation of fibroblast growth factor receptor signaling pathway : IEA:Ensembl negative regulation of interleukin-12 production : IEA:Ensembl negative regulation of nitric oxide mediated signal transduction : IEA:Ensembl negative regulation of plasma membrane long-chain fatty acid transport : IEA:Ensembl negative regulation of plasminogen activation : IEA:Ensembl peptide cross-linking : IEA:Ensembl positive regulation of angiogenesis : IEA:Ensembl positive regulation of blood vessel endothelial cell migration : IEA:Ensembl positive regulation of chemotaxis : IEA:Ensembl positive regulation of endothelial cell apoptotic process : IEA:Ensembl positive regulation of extrinsic apoptotic signaling pathway via death domain receptors : IEA:Ensembl positive regulation of fibroblast migration : IEA:Ensembl positive regulation of macrophage activation : IEA:Ensembl positive regulation of protein kinase B signaling : IEA:Ensembl positive regulation of reactive oxygen species metabolic process : IEA:Ensembl positive regulation of smooth muscle cell proliferation : IEA:Ensembl positive regulation of transforming growth factor beta receptor signaling pathway : IEA:Ensembl positive regulation of translation : IEA:Ensembl positive regulation of tumor necrosis factor biosynthetic process : IEA:Ensembl regulation of cGMP metabolic process : IEA:Ensembl response to calcium ion : IEA:Ensembl response to drug : IEA:Ensembl response to glucose : IEA:Ensembl response to magnesium ion : IEA:Ensembl sprouting angiogenesis : IEA:Ensembl

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}