Amyloid beta precursor protein (M3XPJ8)

Uniprot ID	M3XPJ8
Protein Name	Amyloid beta precursor protein
Gene Name	APP
Species	Mustela putorius furo (European domestic ferret) (Mustela furo)

Signal peptide^(a)	N	Secretome P^(b)	0.295
Function
GO - Molecular function	DNA binding : IEA:Ensembl enzyme binding : IEA:Ensembl identical protein binding : IEA:Ensembl PTB domain binding : IEA:Ensembl serine-type endopeptidase inhibitor activity : IEA:Ensembl signaling receptor binding : IEA:Ensembl transition metal ion binding : IEA:InterPro
GO - Biological process	adult locomotory behavior : IEA:Ensembl amyloid fibril formation : IEA:Ensembl astrocyte activation involved in immune response : IEA:Ensembl axo-dendritic transport : IEA:Ensembl axon midline choice point recognition : IEA:Ensembl cellular copper ion homeostasis : IEA:Ensembl cellular response to amyloid-beta : IEA:Ensembl cholesterol metabolic process : IEA:Ensembl collateral sprouting in absence of injury : IEA:Ensembl dendrite development : IEA:Ensembl endocytosis : IEA:Ensembl extracellular matrix organization : IEA:Ensembl forebrain development : IEA:Ensembl ionotropic glutamate receptor signaling pathway : IEA:Ensembl mating behavior : IEA:Ensembl microglia development : IEA:Ensembl modulation of age-related behavioral decline : IEA:Ensembl modulation of excitatory postsynaptic potential : IEA:Ensembl mRNA polyadenylation : IEA:Ensembl negative regulation of cell proliferation : IEA:Ensembl negative regulation of gene expression : IEA:Ensembl negative regulation of long-term synaptic potentiation : IEA:Ensembl negative regulation of neuron differentiation : IEA:Ensembl neuromuscular process controlling balance : IEA:Ensembl neuron apoptotic process : IEA:Ensembl neuron projection maintenance : IEA:Ensembl neuron remodeling : IEA:Ensembl positive regulation of amyloid fibril formation : IEA:Ensembl positive regulation of amyloid-beta formation : IEA:Ensembl positive regulation of astrocyte activation : IEA:Ensembl positive regulation of ERK1 and ERK2 cascade : IEA:Ensembl positive regulation of G2/M transition of mitotic cell cycle : IEA:Ensembl positive regulation of JNK cascade : IEA:Ensembl positive regulation of long-term synaptic potentiation : IEA:Ensembl positive regulation of microglial cell activation : IEA:Ensembl positive regulation of NF-kappaB transcription factor activity : IEA:Ensembl positive regulation of NIK/NF-kappaB signaling : IEA:Ensembl positive regulation of peptidyl-serine phosphorylation : IEA:Ensembl positive regulation of peptidyl-threonine phosphorylation : IEA:Ensembl positive regulation of protein binding : IEA:Ensembl positive regulation of T cell migration : IEA:Ensembl positive regulation of transcription by RNA polymerase II : IEA:Ensembl protein phosphorylation : IEA:Ensembl regulation of epidermal growth factor-activated receptor activity : IEA:Ensembl regulation of long-term neuronal synaptic plasticity : IEA:Ensembl regulation of multicellular organism growth : IEA:Ensembl regulation of spontaneous synaptic transmission : IEA:Ensembl regulation of synapse structure or activity : IEA:Ensembl regulation of translation : IEA:Ensembl response to oxidative stress : IEA:Ensembl smooth endoplasmic reticulum calcium ion homeostasis : IEA:Ensembl suckling behavior : IEA:Ensembl synaptic growth at neuromuscular junction : IEA:Ensembl tumor necrosis factor production : IEA:Ensembl visual learning : IEA:Ensembl

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}