Clusterin (M3XP98)

Uniprot ID M3XP98
Protein Name Clusterin
Gene Name CLU
Species Mustela putorius furo (European domestic ferret) (Mustela furo)
Signal peptide(a) Y Secretome P(b) 0.401
Function
GO - Molecular function
  • amyloid-beta binding : IEA:Ensembl
  • low-density lipoprotein particle receptor binding : IEA:Ensembl
  • misfolded protein binding : IEA:Ensembl
  • protein-containing complex binding : IEA:Ensembl
  • tau protein binding : IEA:Ensembl
  • ubiquitin protein ligase binding : IEA:Ensembl
GO - Biological process
  • cell morphogenesis : IEA:Ensembl
  • central nervous system myelin maintenance : IEA:Ensembl
  • chaperone-mediated protein complex assembly : IEA:Ensembl
  • chaperone-mediated protein folding : IEA:Ensembl
  • microglial cell activation : IEA:Ensembl
  • microglial cell proliferation : IEA:Ensembl
  • negative regulation of amyloid fibril formation : IEA:Ensembl
  • negative regulation of amyloid-beta formation : IEA:Ensembl
  • negative regulation of cellular response to thapsigargin : IEA:Ensembl
  • negative regulation of cellular response to tunicamycin : IEA:Ensembl
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage : IEA:Ensembl
  • negative regulation of protein homooligomerization : IEA:Ensembl
  • negative regulation of response to endoplasmic reticulum stress : IEA:Ensembl
  • positive regulation of amyloid-beta formation : IEA:Ensembl
  • positive regulation of neurofibrillary tangle assembly : IEA:Ensembl
  • positive regulation of neuron death : IEA:Ensembl
  • positive regulation of NF-kappaB transcription factor activity : IEA:Ensembl
  • positive regulation of nitric oxide biosynthetic process : IEA:Ensembl
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process : IEA:Ensembl
  • positive regulation of protein homooligomerization : IEA:Ensembl
  • positive regulation of receptor-mediated endocytosis : IEA:Ensembl
  • positive regulation of tau-protein kinase activity : IEA:Ensembl
  • positive regulation of tumor necrosis factor production : IEA:Ensembl
  • protein import : IEA:Ensembl
  • protein stabilization : IEA:Ensembl
  • regulation of amyloid-beta clearance : IEA:Ensembl
  • regulation of neuronal signal transduction : IEA:Ensembl
  • response to misfolded protein : IEA:Ensembl
  • response to virus : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.