Serpin family E member 1 (G9KN61)

Uniprot ID G9KN61
Protein Name Serpin family E member 1
Gene Name SERPINE1
Species Mustela putorius furo (European domestic ferret) (Mustela furo)
Signal peptide(a) Y Secretome P(b) 0.582
GO - Molecular function
  • protease binding : IEA:Ensembl
  • serine-type endopeptidase inhibitor activity : IEA:Ensembl
  • signaling receptor binding : IEA:Ensembl
GO - Biological process
  • angiogenesis : IEA:Ensembl
  • cellular response to lipopolysaccharide : IEA:Ensembl
  • chronological cell aging : IEA:Ensembl
  • defense response to Gram-negative bacterium : IEA:Ensembl
  • dentinogenesis : IEA:Ensembl
  • negative regulation of cell adhesion mediated by integrin : IEA:Ensembl
  • negative regulation of endothelial cell apoptotic process : IEA:Ensembl
  • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : IEA:Ensembl
  • negative regulation of fibrinolysis : IEA:Ensembl
  • negative regulation of plasminogen activation : IEA:Ensembl
  • negative regulation of smooth muscle cell migration : IEA:Ensembl
  • negative regulation of smooth muscle cell-matrix adhesion : IEA:Ensembl
  • negative regulation of vascular wound healing : IEA:Ensembl
  • positive regulation of angiogenesis : IEA:Ensembl
  • positive regulation of interleukin-8 production : IEA:Ensembl
  • positive regulation of leukotriene production involved in inflammatory response : IEA:Ensembl
  • positive regulation of monocyte chemotaxis : IEA:Ensembl
  • positive regulation of odontoblast differentiation : IEA:Ensembl
  • positive regulation of receptor-mediated endocytosis : IEA:Ensembl
  • regulation of signaling receptor activity : IEA:Ensembl
  • replicative senescence : IEA:Ensembl
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.