| Signal peptide(a) |
N |
Secretome P(b) |
0.0 |
| Function |
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. . |
| GO - Molecular function |
- actin filament binding : ISO:MGI
- actinin binding : ISO:MGI
- ankyrin binding : IPI:UniProtKB
- ATP binding : IEA:UniProtKB-KW
- calcium ion binding : ISO:MGI
- calmodulin binding : ISO:MGI
- enzyme binding : ISO:MGI
- identical protein binding : ISO:MGI
- muscle alpha-actinin binding : ISO:MGI
- protease binding : ISO:MGI
- protein kinase binding : ISO:MGI
- protein self-association : ISO:MGI
- protein serine/threonine kinase activity : ISO:MGI
- protein tyrosine kinase activity : ISO:MGI
- structural constituent of cytoskeleton : TAS:MGI
- structural constituent of muscle : ISO:MGI
- structural molecule activity conferring elasticity : IBA:GO_Central
- telethonin binding : ISO:MGI
|
| GO - Biological process |
- actin filament organization : IBA:GO_Central
- adult heart development : IMP:MGI
- cardiac muscle contraction : ISO:MGI
- cardiac muscle fiber development : ISO:MGI
- cardiac muscle hypertrophy : ISO:MGI
- cardiac muscle tissue morphogenesis : IMP:MGI
- cardiac myofibril assembly : IMP:MGI
- detection of muscle stretch : ISO:MGI
- forward locomotion : IMP:MGI
- heart development : IEP:BHF-UCL
- heart growth : IMP:MGI
- heart morphogenesis : IMP:MGI
- in utero embryonic development : IMP:MGI
- muscle contraction : IMP:MGI
- positive regulation of gene expression : ISO:MGI
- positive regulation of protein secretion : ISO:MGI
- protein kinase A signaling : ISO:MGI
- regulation of catalytic activity : ISO:MGI
- regulation of protein kinase activity : ISO:MGI
- regulation of relaxation of cardiac muscle : IMP:BHF-UCL
- response to calcium ion : ISO:MGI
- sarcomere organization : IMP:MGI
- sarcomerogenesis : ISO:MGI
- skeletal muscle myosin thick filament assembly : ISO:MGI
- skeletal muscle thin filament assembly : ISO:MGI
- somitogenesis : IEP:BHF-UCL
- striated muscle cell development : IMP:MGI
- striated muscle contraction : IBA:GO_Central
- striated muscle myosin thick filament assembly : IBA:GO_Central
- ventricular system development : IMP:MGI
|