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142799

(P16619)

Uniprot ID P16619
Protein Name
Gene Name
Species -
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. .
GO - Molecular function
  • CCR chemokine receptor binding : IBA:GO_Central
  • chemokine activity : IBA:GO_Central
GO - Biological process
  • cellular response to interferon-gamma : IBA:GO_Central
  • cellular response to interleukin-1 : IBA:GO_Central
  • cellular response to tumor necrosis factor : IBA:GO_Central
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • cytokine-mediated signaling pathway : TAS:Reactome
  • G-protein coupled receptor signaling pathway : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • lymphocyte chemotaxis : IBA:GO_Central
  • monocyte chemotaxis : IBA:GO_Central
  • negative regulation of cell proliferation : TAS:UniProtKB
  • neutrophil chemotaxis : IBA:GO_Central
  • positive regulation of ERK1 and ERK2 cascade : IBA:GO_Central
  • positive regulation of GTPase activity : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.