(P08581)

Uniprot ID P08581
Protein Name
Gene Name
Species -
Signal peptide(a) N Secretome P(b)
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). .Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • hepatocyte growth factor-activated receptor activity : TAS:ProtInc
  • identical protein binding : IPI:IntAct
  • phosphatidylinositol-4,5-bisphosphate 3-kinase activity : TAS:Reactome
  • protein phosphatase binding : IPI:UniProtKB
  • protein tyrosine kinase activity : TAS:Reactome
  • Ras guanyl-nucleotide exchange factor activity : TAS:Reactome
GO - Biological process
  • branching morphogenesis of an epithelial tube : IMP:UniProtKB
  • cell proliferation : TAS:ProtInc
  • cell surface receptor signaling pathway : NAS:UniProtKB
  • endothelial cell morphogenesis : IDA:UniProtKB
  • entry of bacterium into host cell : TAS:Reactome
  • establishment of skin barrier : IMP:CAFA
  • MAPK cascade : TAS:Reactome
  • negative regulation of autophagy : NAS:ParkinsonsUK-UCL
  • negative regulation of guanyl-nucleotide exchange factor activity : IDA:CAFA
  • negative regulation of hydrogen peroxide-mediated programmed cell death : IMP:BHF-UCL
  • negative regulation of Rho protein signal transduction : IDA:CAFA
  • negative regulation of stress fiber assembly : IDA:CAFA
  • negative regulation of thrombin-activated receptor signaling pathway : IDA:CAFA
  • positive chemotaxis : IDA:UniProtKB
  • positive regulation of endothelial cell chemotaxis : IMP:UniProtKB
  • positive regulation of microtubule polymerization : IMP:CAFA
  • positive regulation of protein kinase B signaling : TAS:Reactome
  • positive regulation of transcription by RNA polymerase II : IDA:BHF-UCL
  • semaphorin-plexin signaling pathway : IDA:UniProtKB
  • signal transduction : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.