Cathepsin Z (Q9UBR2)

Uniprot ID Q9UBR2
Protein Name Cathepsin Z
Gene Name CTSZ
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b)
Function Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.
GO - Molecular function
  • carboxypeptidase activity : IMP:CAFA
  • cysteine-type endopeptidase activity : IBA:GO_Central
  • cysteine-type peptidase activity : TAS:Reactome
GO - Biological process
  • angiotensin maturation : TAS:Reactome
  • COPII vesicle coating : TAS:Reactome
  • epithelial tube branching involved in lung morphogenesis : IEA:Ensembl
  • ER to Golgi vesicle-mediated transport : TAS:Reactome
  • negative regulation of neuron projection development : IEA:Ensembl
  • negative regulation of plasminogen activation : IMP:CAFA
  • negative regulation of protein binding : IDA:CAFA
  • neutrophil degranulation : TAS:Reactome
  • positive regulation of neural precursor cell proliferation : IEA:Ensembl
  • positive regulation of neuron apoptotic process : IEA:Ensembl
  • proteolysis : IMP:CAFA
  • proteolysis involved in cellular protein catabolic process : IBA:GO_Central
  • regulation of neuron death : IGI:CAFA
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.