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140114

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Q9NWQ8)

Uniprot ID Q9NWQ8
Protein Name Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Gene Name PAG1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. .
GO - Molecular function
  • SH2 domain binding : IDA:HGNC-UCL
  • SH3/SH2 adaptor activity : NAS:HGNC-UCL
GO - Biological process
  • adaptive immune response : IEA:UniProtKB-KW
  • intracellular signal transduction : IDA:HGNC-UCL
  • negative regulation of T cell activation : IBA:GO_Central
  • regulation of T cell activation : IDA:ProtInc
  • signal transduction : TAS:ProtInc
  • T cell receptor signaling pathway : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.