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140111

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Q9HCR9)

Uniprot ID Q9HCR9
Protein Name Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Gene Name PDE11A
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. .
GO - Molecular function
  • 3',5'-cyclic-GMP phosphodiesterase activity : IEA:UniProtKB-EC
  • 3',5'-cyclic-nucleotide phosphodiesterase activity : TAS:ProtInc
  • cGMP binding : IDA:UniProtKB
  • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity : IDA:UniProtKB
  • cyclic-nucleotide phosphodiesterase activity : NAS:UniProtKB
  • metal ion binding : IEA:UniProtKB-KW
GO - Biological process
  • G protein-coupled receptor signaling pathway : TAS:Reactome
  • metabolic process : IEA:UniProtKB-KW
  • negative regulation of cAMP-mediated signaling : IBA:GO_Central
  • negative regulation of cGMP-mediated signaling : IBA:GO_Central
  • signal transduction : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.