| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). . |
| GO - Molecular function |
- calcium-dependent protein binding : IPI:UniProtKB
- DNA binding : TAS:ProtInc
- nuclear receptor transcription coactivator activity : IEA:Ensembl
- protein homodimerization activity : IPI:UniProtKB
- protein-containing complex binding : IDA:UniProtKB
- transcription corepressor activity : TAS:ProtInc
- ubiquitin binding : IDA:UniProtKB
- ubiquitin protein ligase binding : IPI:UniProtKB
- virion binding : IDA:UniProtKB
|
| GO - Biological process |
- autophagosome maturation : TAS:ParkinsonsUK-UCL
- cell cycle arrest : IEA:Ensembl
- cell division : IEA:UniProtKB-KW
- endosomal transport : TAS:Reactome
- endosome to lysosome transport : IEA:Ensembl
- exosomal secretion : IEA:Ensembl
- extracellular transport : IMP:UniProtKB
- intracellular transport of virus : TAS:Reactome
- keratinocyte differentiation : IEA:Ensembl
- macroautophagy : TAS:ParkinsonsUK-UCL
- multivesicular body assembly : TAS:ParkinsonsUK-UCL
- negative regulation of cell population proliferation : IEA:Ensembl
- negative regulation of epidermal growth factor receptor signaling pathway : IMP:ParkinsonsUK-UCL
- negative regulation of epidermal growth factor-activated receptor activity : IMP:UniProtKB
- negative regulation of transcription, DNA-templated : IEA:Ensembl
- positive regulation of exosomal secretion : IMP:UniProtKB
- positive regulation of ubiquitin-dependent endocytosis : IEA:Ensembl
- positive regulation of viral budding via host ESCRT complex : IMP:UniProtKB
- positive regulation of viral release from host cell : IMP:UniProtKB
- protein monoubiquitination : IEA:Ensembl
- protein transport : IEA:UniProtKB-KW
- regulation of cell growth : IEA:Ensembl
- regulation of extracellular exosome assembly : IMP:UniProtKB
- regulation of MAP kinase activity : IMP:UniProtKB
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway : IDA:HGNC-UCL
- viral budding : IMP:UniProtKB
- viral budding via host ESCRT complex : TAS:ParkinsonsUK-UCL
- viral life cycle : TAS:Reactome
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