Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
140077

Inactive phospholipase C-like protein 1 (Q15111)

Uniprot ID Q15111
Protein Name Inactive phospholipase C-like protein 1
Gene Name PLCL1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. .
GO - Molecular function
  • GABA receptor binding : IEA:InterPro
  • inositol 1,4,5 trisphosphate binding : IEA:InterPro
  • phosphatidylinositol phospholipase C activity : IEA:InterPro
  • phospholipase C activity : TAS:ProtInc
GO - Biological process
  • gamma-aminobutyric acid signaling pathway : IEA:Ensembl
  • intracellular signal transduction : TAS:ProtInc
  • lipid metabolic process : IEA:InterPro
  • positive regulation of receptor binding : IEA:Ensembl
  • regulation of peptidyl-serine phosphorylation : IEA:Ensembl
  • regulation of synaptic transmission, GABAergic : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.