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140075

Bleomycin hydrolase (Q13867)

Uniprot ID Q13867
Protein Name Bleomycin hydrolase
Gene Name BLMH
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. .
GO - Molecular function
  • aminopeptidase activity : EXP:Reactome
  • carboxypeptidase activity : TAS:ProtInc
  • cysteine-type endopeptidase activity : TAS:ProtInc
  • cysteine-type peptidase activity : TAS:ProtInc
  • identical protein binding : IPI:IntAct
GO - Biological process
  • homocysteine catabolic process : IBA:GO_Central
  • protein polyubiquitination : TAS:Reactome
  • proteolysis : TAS:ProtInc
  • response to drug : IEA:Ensembl
  • response to toxic substance : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.