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140074

Eukaryotic translation initiation factor 4E-binding protein 1 (Q13541)

Uniprot ID Q13541
Protein Name Eukaryotic translation initiation factor 4E-binding protein 1
Gene Name EIF4EBP1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. .
GO - Molecular function
  • eukaryotic initiation factor 4E binding : IDA:AgBase
  • translation repressor activity : IDA:UniProtKB
GO - Biological process
  • cellular response to dexamethasone stimulus : IEA:Ensembl
  • G1/S transition of mitotic cell cycle : IMP:UniProtKB
  • insulin receptor signaling pathway : IEA:Ensembl
  • IRES-dependent translational initiation of linear mRNA : IEA:Ensembl
  • negative regulation of translational initiation : IDA:UniProtKB
  • positive regulation of mitotic cell cycle : IMP:UniProtKB
  • TOR signaling : IDA:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.