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140072

Treacle protein (Q13428)

Uniprot ID Q13428
Protein Name Treacle protein
Gene Name TCOF1
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). .
GO - Molecular function
  • protein heterodimerization activity : IPI:UniProtKB
  • RNA binding : HDA:UniProtKB
  • RNA polymerase I core binding : IDA:UniProtKB
  • scaffold protein binding : IPI:CAFA
  • transporter activity : TAS:ProtInc
GO - Biological process
  • neural crest cell development : IMP:UniProtKB
  • neural crest formation : IMP:UniProtKB
  • regulation of translation : IMP:UniProtKB
  • skeletal system development : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.