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140070

Platelet-activating factor acetylhydrolase (Q13093)

Uniprot ID Q13093
Protein Name Platelet-activating factor acetylhydrolase
Gene Name PLA2G7
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
GO - Molecular function
  • 1-alkyl-2-acetylglycerophosphocholine esterase activity : IDA:BHF-UCL
  • calcium-independent phospholipase A2 activity : IDA:BHF-UCL
  • hydrolase activity, acting on ester bonds : TAS:Reactome
  • phospholipid binding : IDA:BHF-UCL
GO - Biological process
  • lipid catabolic process : IEA:UniProtKB-KW
  • lipid oxidation : IDA:BHF-UCL
  • low-density lipoprotein particle remodeling : IDA:BHF-UCL
  • plasma lipoprotein particle oxidation : IDA:BHF-UCL
  • platelet activating factor metabolic process : IDA:BHF-UCL
  • positive regulation of inflammatory response : TAS:BHF-UCL
  • positive regulation of monocyte chemotaxis : IDA:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.