| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity). . |
| GO - Molecular function |
- lipoprotein particle receptor binding : ISS:BHF-UCL
- metal ion binding : IEA:UniProtKB-KW
- serine-type peptidase activity : IEA:UniProtKB-KW
- very-low-density lipoprotein particle receptor binding : ISS:BHF-UCL
|
| GO - Biological process |
- associative learning : IEA:Ensembl
- axon guidance : ISS:UniProtKB
- brain development : ISS:UniProtKB
- cell adhesion : IEA:UniProtKB-KW
- cell morphogenesis involved in differentiation : ISS:UniProtKB
- central nervous system development : ISS:UniProtKB
- cerebral cortex tangential migration : ISS:UniProtKB
- dendrite development : IEA:Ensembl
- glial cell differentiation : ISS:UniProtKB
- hippocampus development : ISS:BHF-UCL
- lateral motor column neuron migration : IEA:Ensembl
- layer formation in cerebral cortex : IEA:Ensembl
- locomotory behavior : IEA:Ensembl
- long-term memory : IEA:Ensembl
- long-term synaptic potentiation : IEA:Ensembl
- modulation of chemical synaptic transmission : ISS:BHF-UCL
- neuron migration : ISS:UniProtKB
- NMDA glutamate receptor clustering : IEA:Ensembl
- peptidyl-tyrosine phosphorylation : ISS:UniProtKB
- positive regulation of AMPA receptor activity : ISS:BHF-UCL
- positive regulation of CREB transcription factor activity : ISS:BHF-UCL
- positive regulation of dendritic spine morphogenesis : ISS:BHF-UCL
- positive regulation of excitatory postsynaptic potential : ISS:BHF-UCL
- positive regulation of lateral motor column neuron migration : IEA:Ensembl
- positive regulation of long-term synaptic potentiation : ISS:BHF-UCL
- positive regulation of neuron projection development : ISS:BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation : ISS:BHF-UCL
- positive regulation of phosphatidylinositol 3-kinase signaling : IEA:Ensembl
- positive regulation of protein kinase activity : ISS:UniProtKB
- positive regulation of protein tyrosine kinase activity : ISS:BHF-UCL
- positive regulation of small GTPase mediated signal transduction : ISS:UniProtKB
- positive regulation of synapse maturation : ISS:BHF-UCL
- positive regulation of synaptic transmission, glutamatergic : ISS:BHF-UCL
- positive regulation of TOR signaling : IEA:Ensembl
- postsynaptic density protein 95 clustering : IEA:Ensembl
- receptor localization to synapse : IEA:Ensembl
- reelin-mediated signaling pathway : ISS:BHF-UCL
- regulation of behavior : ISS:BHF-UCL
- regulation of NMDA receptor activity : ISS:BHF-UCL
- response to pain : ISS:UniProtKB
- spinal cord patterning : ISS:UniProtKB
- ventral spinal cord development : IEA:Ensembl
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