| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). . |
| GO - Molecular function |
- cadherin binding : HDA:BHF-UCL
- identical protein binding : IPI:IntAct
- ion channel binding : IPI:SynGO-UCL
- protein domain specific binding : IEA:Ensembl
- protein kinase binding : IPI:UniProtKB
- RNA binding : HDA:UniProtKB
- transcription factor binding : IPI:UniProtKB
- ubiquitin protein ligase binding : IPI:ParkinsonsUK-UCL
|
| GO - Biological process |
- angiogenesis : IEA:Ensembl
- cytokine-mediated signaling pathway : TAS:Reactome
- ERK1 and ERK2 cascade : IEA:Ensembl
- establishment of Golgi localization : IMP:UniProtKB
- Golgi reassembly : IMP:UniProtKB
- lung development : IEA:Ensembl
- membrane organization : TAS:Reactome
- negative regulation of apoptotic process : TAS:ProtInc
- platelet activation : TAS:Reactome
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway : TAS:Reactome
- protein phosphorylation : IMP:UniProtKB
- protein targeting : IEA:Ensembl
- regulation of ERK1 and ERK2 cascade : IDA:UniProtKB
- regulation of mRNA stability : TAS:Reactome
- regulation of synapse maturation : IDA:SynGO
- respiratory system process : IEA:Ensembl
- signal transduction : IMP:UniProtKB
- synaptic target recognition : IEA:Ensembl
- tube formation : IEA:Ensembl
|