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140050

40S ribosomal protein S23 (P62266)

Uniprot ID P62266
Protein Name 40S ribosomal protein S23
Gene Name RPS23
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692). .
GO - Molecular function
  • RNA binding : HDA:UniProtKB
  • structural constituent of ribosome : IMP:UniProtKB
GO - Biological process
  • cytoplasmic translation : IDA:UniProtKB
  • maintenance of translational fidelity : IMP:UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay : TAS:Reactome
  • SRP-dependent cotranslational protein targeting to membrane : TAS:Reactome
  • stress granule assembly : IMP:UniProtKB
  • translation : IMP:UniProtKB
  • translational initiation : TAS:Reactome
  • viral transcription : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.