| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. . |
| GO - Molecular function |
- apolipoprotein A-I receptor binding : IPI:BHF-UCL
- GBD domain binding : IPI:CAFA
- GTP binding : IDA:UniProtKB
- GTPase activity : IDA:UniProtKB
- identical protein binding : IPI:IntAct
- protein kinase binding : IDA:BHF-UCL
- protein serine/threonine kinase activity : TAS:Reactome
- thioesterase binding : IPI:UniProtKB
- ubiquitin protein ligase activity : IDA:AgBase
|
| GO - Biological process |
- actin cytoskeleton organization : IDA:UniProtKB
- actin filament organization : IMP:UniProtKB
- blood coagulation : TAS:Reactome
- cell junction assembly : IMP:UniProtKB
- dendritic spine morphogenesis : ISS:UniProtKB
- ephrin receptor signaling pathway : TAS:Reactome
- establishment of epithelial cell apical/basal polarity : IMP:UniProtKB
- establishment of Golgi localization : ISS:BHF-UCL
- establishment or maintenance of cell polarity : TAS:UniProtKB
- Fc-gamma receptor signaling pathway involved in phagocytosis : TAS:Reactome
- Golgi organization : ISS:BHF-UCL
- integrin-mediated signaling pathway : IMP:BHF-UCL
- interleukin-12-mediated signaling pathway : TAS:Reactome
- macrophage differentiation : TAS:UniProtKB
- negative regulation of epidermal growth factor receptor signaling pathway : TAS:Reactome
- negative regulation of protein complex assembly : IPI:UniProtKB
- neuropilin signaling pathway : IMP:BHF-UCL
- organelle transport along microtubule : ISS:BHF-UCL
- phagocytosis, engulfment : IMP:UniProtKB
- positive regulation of actin cytoskeleton reorganization : IMP:BHF-UCL
- positive regulation of cell growth : IMP:AgBase
- positive regulation of cytokinesis : IMP:UniProtKB
- positive regulation of filopodium assembly : IMP:BHF-UCL
- positive regulation of lamellipodium assembly : IMP:CAFA
- positive regulation of muscle cell differentiation : TAS:Reactome
- positive regulation of pseudopodium assembly : IDA:UniProtKB
- positive regulation of stress fiber assembly : IMP:BHF-UCL
- positive regulation of substrate adhesion-dependent cell spreading : IDA:UniProtKB
- regulation of attachment of spindle microtubules to kinetochore : IMP:UniProtKB
- regulation of filopodium assembly : IDA:UniProtKB
- regulation of lamellipodium assembly : IGI:CAFA
- regulation of small GTPase mediated signal transduction : TAS:Reactome
- regulation of stress fiber assembly : IGI:CAFA
- small GTPase mediated signal transduction : IEA:InterPro
- substantia nigra development : HEP:UniProtKB
- T cell costimulation : TAS:Reactome
- vascular endothelial growth factor receptor signaling pathway : TAS:Reactome
- viral RNA genome replication : IMP:ParkinsonsUK-UCL
- Wnt signaling pathway, planar cell polarity pathway : NAS:ParkinsonsUK-UCL
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