Actin, cytoplasmic 1 (P60709)

Uniprot ID P60709
Protein Name Actin, cytoplasmic 1
Gene Name ACTB
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • identical protein binding : IPI:IntAct
  • kinesin binding : IPI:UniProtKB
  • nitric-oxide synthase binding : IPI:BHF-UCL
  • protein kinase binding : IPI:ARUK-UCL
  • structural constituent of cytoskeleton : TAS:UniProtKB
  • structural constituent of postsynaptic actin cytoskeleton : IDA:SynGO
  • Tat protein binding : IPI:BHF-UCL
GO - Biological process
  • ATP-dependent chromatin remodeling : HDA:UniProtKB
  • cell junction assembly : TAS:Reactome
  • cell motility : IMP:UniProtKB
  • cellular response to cytochalasin B : IMP:UniProtKB
  • ephrin receptor signaling pathway : TAS:Reactome
  • Fc-gamma receptor signaling pathway involved in phagocytosis : TAS:Reactome
  • membrane organization : TAS:Reactome
  • negative regulation of protein binding : ISS:ARUK-UCL
  • platelet aggregation : HMP:UniProtKB
  • positive regulation of gene expression, epigenetic : TAS:Reactome
  • postsynaptic actin cytoskeleton organization : IDA:SynGO
  • protein deubiquitination : TAS:Reactome
  • retina homeostasis : HEP:UniProtKB
  • substantia nigra development : HEP:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.