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140034

T-complex protein 1 subunit delta (P50991)

Uniprot ID P50991
Protein Name T-complex protein 1 subunit delta
Gene Name CCT4
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • RNA binding : HDA:UniProtKB
  • unfolded protein binding : TAS:ProtInc
GO - Biological process
  • binding of sperm to zona pellucida : IEA:Ensembl
  • positive regulation of establishment of protein localization to telomere : IMP:BHF-UCL
  • positive regulation of protein localization to Cajal body : HMP:BHF-UCL
  • positive regulation of telomerase activity : IMP:BHF-UCL
  • positive regulation of telomerase RNA localization to Cajal body : IMP:BHF-UCL
  • positive regulation of telomere maintenance via telomerase : IMP:BHF-UCL
  • protein folding : TAS:Reactome
  • protein stabilization : IMP:BHF-UCL
  • scaRNA localization to Cajal body : IMP:BHF-UCL
  • toxin transport : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.