Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
140032

Alanine--tRNA ligase, cytoplasmic (P49588)

Uniprot ID P49588
Protein Name Alanine--tRNA ligase, cytoplasmic
Gene Name AARS
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:28493438). .
GO - Molecular function
  • alanine-tRNA ligase activity : IDA:UniProtKB
  • amino acid binding : IBA:GO_Central
  • aminoacyl-tRNA editing activity : IDA:UniProtKB
  • ATP binding : IEA:UniProtKB-KW
  • metal ion binding : IEA:UniProtKB-KW
  • tRNA binding : IBA:GO_Central
GO - Biological process
  • alanyl-tRNA aminoacylation : IDA:UniProtKB
  • cellular response to calcium ion : HEP:ARUK-UCL
  • cerebellar Purkinje cell layer development : IEA:Ensembl
  • negative regulation of neuron apoptotic process : IEA:Ensembl
  • neuromuscular process controlling balance : IEA:Ensembl
  • tRNA aminoacylation for protein translation : TAS:Reactome
  • tRNA modification : IBA:GO_Central
  • tRNA processing : TAS:ProtInc
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.