| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. . |
| GO - Molecular function |
- cytoskeletal protein binding : IEA:Ensembl
- ephrin receptor binding : IPI:UniProtKB
- insulin-like growth factor receptor binding : IEA:Ensembl
- phosphotyrosine residue binding : IPI:CAFA
- protein phosphorylated amino acid binding : IDA:CAFA
- protein self-association : IDA:CAFA
- protein tyrosine kinase binding : IPI:CAFA
- scaffold protein binding : IEA:Ensembl
- SH2 domain binding : IPI:UniProtKB
- SH3 domain binding : IPI:CAFA
- SH3/SH2 adaptor activity : IDA:CAFA
|
| GO - Biological process |
- activation of MAPKK activity : TAS:Reactome
- cellular response to endothelin : IEA:Ensembl
- cellular response to insulin-like growth factor stimulus : IEA:Ensembl
- cellular response to nerve growth factor stimulus : IEA:Ensembl
- cellular response to nitric oxide : IEA:Ensembl
- cellular response to transforming growth factor beta stimulus : IEA:Ensembl
- cytokine-mediated signaling pathway : TAS:Reactome
- ephrin receptor signaling pathway : IDA:UniProtKB
- Fc-gamma receptor signaling pathway involved in phagocytosis : TAS:Reactome
- negative regulation of cell motility : IDA:CAFA
- negative regulation of natural killer cell mediated cytotoxicity : IEA:Ensembl
- negative regulation of wound healing : IDA:CAFA
- positive regulation of cell growth : IDA:CAFA
- positive regulation of smooth muscle cell migration : IEA:Ensembl
- positive regulation of substrate adhesion-dependent cell spreading : IMP:UniProtKB
- regulation of actin cytoskeleton organization : IDA:UniProtKB
- regulation of cell shape : IMP:CAFA
- regulation of GTPase activity : IDA:UniProtKB
- regulation of protein binding : IMP:CAFA
- regulation of Rac protein signal transduction : IEA:Ensembl
- regulation of signal transduction : IDA:CAFA
- regulation of transcription by RNA polymerase II : TAS:ProtInc
- response to cholecystokinin : IEA:Ensembl
- response to hepatocyte growth factor : IEA:Ensembl
- response to hydrogen peroxide : IEA:Ensembl
- response to yeast : IEA:Ensembl
- SH2 domain-mediated complex assembly : IDA:CAFA
- vascular endothelial growth factor receptor signaling pathway : TAS:Reactome
|