Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
140026

Cathepsin K (P43235)

Uniprot ID P43235
Protein Name Cathepsin K
Gene Name CTSK
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
GO - Molecular function
  • collagen binding : IDA:BHF-UCL
  • cysteine-type endopeptidase activity : IDA:BHF-UCL
  • cysteine-type peptidase activity : TAS:ProtInc
  • fibronectin binding : IPI:BHF-UCL
  • proteoglycan binding : IPI:BHF-UCL
  • serine-type endopeptidase activity : TAS:Reactome
GO - Biological process
  • autophagy of mitochondrion : HMP:ParkinsonsUK-UCL
  • bone resorption : IEA:Ensembl
  • collagen catabolic process : IDA:BHF-UCL
  • extracellular matrix disassembly : TAS:Reactome
  • intramembranous ossification : IEA:Ensembl
  • proteolysis : TAS:ProtInc
  • proteolysis involved in cellular protein catabolic process : IDA:BHF-UCL
  • regulation of keratinocyte differentiation : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.