Glial cell line-derived neurotrophic factor (P39905)

Uniprot ID P39905
Protein Name Glial cell line-derived neurotrophic factor
Gene Name GDNF
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. .
GO - Molecular function
  • chemoattractant activity involved in axon guidance : TAS:ARUK-UCL
  • growth factor activity : IBA:GO_Central
  • protein homodimerization activity : IDA:UniProtKB
  • signaling receptor binding : TAS:ProtInc
GO - Biological process
  • adult locomotory behavior : TAS:BHF-UCL
  • axon guidance : TAS:Reactome
  • branching involved in ureteric bud morphogenesis : ISS:UniProtKB
  • commissural neuron axon guidance : ISS:ARUK-UCL
  • dorsal spinal cord development : ISS:ARUK-UCL
  • embryonic organ development : ISS:ARUK-UCL
  • enteric nervous system development : ISS:UniProtKB
  • MAPK cascade : TAS:Reactome
  • mesenchymal to epithelial transition involved in metanephros morphogenesis : IEA:Ensembl
  • metanephros development : ISS:UniProtKB
  • mRNA stabilization : IDA:BHF-UCL
  • negative regulation of apoptotic process : TAS:ProtInc
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : IDA:UniProtKB
  • negative regulation of neuron apoptotic process : IDA:UniProtKB
  • nervous system development : TAS:ARUK-UCL
  • neural crest cell migration : IDA:MGI
  • neuron projection development : IDA:MGI
  • organ induction : IEA:Ensembl
  • peripheral nervous system development : IBA:GO_Central
  • peristalsis : ISS:UniProtKB
  • positive regulation of branching involved in ureteric bud morphogenesis : IDA:UniProtKB
  • positive regulation of cell differentiation : IGI:MGI
  • positive regulation of cell population proliferation : IDA:MGI
  • positive regulation of dopamine secretion : TAS:BHF-UCL
  • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis : IEA:Ensembl
  • positive regulation of monooxygenase activity : IDA:BHF-UCL
  • positive regulation of transcription by RNA polymerase II : IDA:BHF-UCL
  • positive regulation of ureteric bud formation : IDA:UniProtKB
  • postganglionic parasympathetic fiber development : ISS:UniProtKB
  • postsynaptic membrane organization : IEA:Ensembl
  • regulation of dopamine uptake involved in synaptic transmission : IDA:UniProtKB
  • regulation of gene expression : IGI:MGI
  • regulation of morphogenesis of a branching structure : ISS:UniProtKB
  • regulation of semaphorin-plexin signaling pathway : ISS:ARUK-UCL
  • regulation of stem cell differentiation : TAS:ParkinsonsUK-UCL
  • signal transduction : TAS:ProtInc
  • sympathetic nervous system development : ISS:UniProtKB
  • ureteric bud formation : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.