| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. . |
| GO - Molecular function |
- calmodulin binding : IEA:UniProtKB-KW
- carbon-sulfur lyase activity : TAS:Reactome
- cystathionine gamma-lyase activity : IDA:UniProtKB
- cystathionine gamma-synthase activity : IBA:GO_Central
- homocysteine desulfhydrase activity : TAS:Reactome
- identical protein binding : IPI:IntAct
- L-cysteine desulfhydrase activity : TAS:Reactome
- L-cystine L-cysteine-lyase (deaminating) : IMP:UniProtKB
- pyridoxal phosphate binding : IDA:UniProtKB
|
| GO - Biological process |
- 'de novo' L-methionine biosynthetic process : IBA:GO_Central
- cellular response to leukemia inhibitory factor : IEA:Ensembl
- cysteine biosynthetic process : IDA:UniProtKB
- cysteine biosynthetic process via cystathionine : IDA:BHF-UCL
- cysteine metabolic process : TAS:ProtInc
- endoplasmic reticulum unfolded protein response : TAS:UniProtKB
- hydrogen sulfide biosynthetic process : IDA:UniProtKB
- negative regulation of apoptotic signaling pathway : IEA:Ensembl
- positive regulation of aortic smooth muscle cell differentiation : IMP:BHF-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling : IEA:Ensembl
- positive regulation of NF-kappaB transcription factor activity : IEA:Ensembl
- protein homotetramerization : IPI:UniProtKB
- protein sulfhydration : IMP:UniProtKB
- protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine : IDA:UniProtKB
- sulfur amino acid catabolic process : TAS:Reactome
- transsulfuration : IDA:BHF-UCL
|