Proteasome subunit alpha type-5 (P28066)

Uniprot ID P28066
Protein Name Proteasome subunit alpha type-5
Gene Name PSMA5
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b)
Function Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). .
GO - Molecular function
  • threonine-type endopeptidase activity : IEA:UniProtKB-KW
GO - Biological process
  • neutrophil degranulation : TAS:Reactome
  • post-translational protein modification : TAS:Reactome
  • proteasome-mediated ubiquitin-dependent protein catabolic process : IEA:InterPro
  • protein deubiquitination : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.