Pentraxin-related protein PTX3 (P26022)

Uniprot ID P26022
Protein Name Pentraxin-related protein PTX3
Gene Name PTX3
Species Homo sapiens (Human)
Signal peptide(a) Y Secretome P(b)
Function Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. .
GO - Molecular function
  • (1->3)-beta-D-glucan binding : IEA:Ensembl
  • complement component C1q binding : IDA:BHF-UCL
  • identical protein binding : IPI:IntAct
  • virion binding : IDA:BHF-UCL
GO - Biological process
  • inflammatory response : TAS:ProtInc
  • innate immune response : IDA:BHF-UCL
  • negative regulation by host of viral exo-alpha-sialidase activity : IDA:BHF-UCL
  • negative regulation by host of viral glycoprotein metabolic process : IDA:BHF-UCL
  • negative regulation of exo-alpha-sialidase activity : IDA:BHF-UCL
  • negative regulation of glycoprotein metabolic process : IDA:BHF-UCL
  • negative regulation of viral entry into host cell : IDA:BHF-UCL
  • neutrophil degranulation : TAS:Reactome
  • opsonization : IEA:Ensembl
  • positive regulation of nitric oxide biosynthetic process : IEA:Ensembl
  • positive regulation of phagocytosis : IEA:Ensembl
  • response to yeast : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.