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140001

Cathepsin S (P25774)

Uniprot ID P25774
Protein Name Cathepsin S
Gene Name CTSS
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.
GO - Molecular function
  • collagen binding : IDA:BHF-UCL
  • cysteine-type endopeptidase activity : IDA:CAFA
  • fibronectin binding : IPI:BHF-UCL
  • laminin binding : IDA:BHF-UCL
  • proteoglycan binding : IPI:BHF-UCL
  • serine-type endopeptidase activity : TAS:Reactome
GO - Biological process
  • adaptive immune response : IEP:UniProtKB
  • antigen processing and presentation : TAS:UniProtKB
  • antigen processing and presentation of exogenous peptide antigen via MHC class II : TAS:Reactome
  • antigen processing and presentation of peptide antigen : IDA:CACAO
  • basement membrane disassembly : IDA:BHF-UCL
  • cellular response to thyroid hormone stimulus : IEP:UniProtKB
  • collagen catabolic process : IDA:BHF-UCL
  • extracellular matrix disassembly : TAS:Reactome
  • immune response : TAS:ProtInc
  • neutrophil degranulation : TAS:Reactome
  • positive regulation of cation channel activity : IDA:CACAO
  • protein processing : IDA:CACAO
  • proteolysis : IDA:CAFA
  • proteolysis involved in cellular protein catabolic process : IDA:BHF-UCL
  • response to acidic pH : IDA:CACAO
  • toll-like receptor signaling pathway : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.