| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro. |
| GO - Molecular function |
- antioxidant activity : NAS:UniProtKB
- cadmium ion binding : IDA:UniProtKB
- copper ion binding : IDA:UniProtKB
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process : IDA:UniProtKB
- drug binding : IDA:UniProtKB
- protein kinase activator activity : IDA:UniProtKB
- zinc ion binding : IDA:UniProtKB
|
| GO - Biological process |
- activation of protein kinase B activity : IDA:UniProtKB
- astrocyte development : ISS:UniProtKB
- brain development : IEA:Ensembl
- cadmium ion homeostasis : IDA:UniProtKB
- cell proliferation : TAS:ProtInc
- cellular lipid catabolic process : ISS:UniProtKB
- cellular metal ion homeostasis : TAS:UniProtKB
- cellular response to cadmium ion : IDA:UniProtKB
- cellular response to drug : IDA:UniProtKB
- cellular response to hypoxia : IEP:UniProtKB
- cellular response to nitric oxide : IDA:UniProtKB
- cellular response to oxidative stress : IEP:UniProtKB
- cellular zinc ion homeostasis : ISS:UniProtKB
- cholesterol catabolic process : ISS:UniProtKB
- energy reserve metabolic process : ISS:UniProtKB
- ERK1 and ERK2 cascade : IDA:UniProtKB
- histone modification : IMP:UniProtKB
- leptin-mediated signaling pathway : ISS:UniProtKB
- negative regulation of apoptotic process : IDA:UniProtKB
- negative regulation of autophagy : ISS:UniProtKB
- negative regulation of axon extension : IDA:UniProtKB
- negative regulation of cell growth : IDA:UniProtKB
- negative regulation of cysteine-type endopeptidase activity : IDA:UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : IDA:UniProtKB
- negative regulation of hydrogen peroxide catabolic process : IEA:Ensembl
- negative regulation of necrotic cell death : IDA:UniProtKB
- negative regulation of neuron apoptotic process : ISS:UniProtKB
- negative regulation of oxidoreductase activity : IDA:UniProtKB
- negative regulation of reactive oxygen species metabolic process : IDA:UniProtKB
- negative regulation of transcription, DNA-templated : ISS:UniProtKB
- positive regulation of catalytic activity : ISS:UniProtKB
- positive regulation of cell death : IDA:UniProtKB
- positive regulation of ERK1 and ERK2 cascade : IDA:UniProtKB
- positive regulation of gene expression : IDA:UniProtKB
- positive regulation of lysosomal membrane permeability : ISS:UniProtKB
- positive regulation of necrotic cell death : IDA:UniProtKB
- positive regulation of oxygen metabolic process : ISS:UniProtKB
- positive regulation of protein phosphorylation : IDA:UniProtKB
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress : IDA:UniProtKB
- positive regulation of transcription, DNA-templated : IDA:UniProtKB
- positive regulation of vascular endothelial growth factor receptor signaling pathway : IDA:UniProtKB
- protein import into nucleus, translocation : IDA:UniProtKB
- protein kinase B signaling : IDA:UniProtKB
- protein stabilization : IDA:UniProtKB
- regulation of protein glycosylation : ISS:UniProtKB
- regulation of response to food : ISS:UniProtKB
- removal of superoxide radicals : IDA:UniProtKB
- response to hypoxia : IDA:UniProtKB
- response to metal ion : TAS:Reactome
- zinc ion homeostasis : IDA:UniProtKB
- zinc ion transport : ISS:UniProtKB
|