| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. . |
| GO - Molecular function |
- DNA topoisomerase binding : IPI:CAFA
- identical protein binding : IPI:IntAct
- mRNA 5'-UTR binding : IDA:CAFA
- protein C-terminus binding : IPI:UniProtKB
- RNA binding : IDA:UniProtKB
- telomeric DNA binding : IDA:UniProtKB
|
| GO - Biological process |
- angiogenesis : IDA:UniProtKB
- cellular response to epidermal growth factor stimulus : IEA:Ensembl
- cellular response to leukemia inhibitory factor : IEA:Ensembl
- negative regulation of translation : IMP:CAFA
- positive regulation of transcription by RNA polymerase II : IEA:Ensembl
- positive regulation of transcription of nucleolar large rRNA by RNA polymerase I : IMP:UniProtKB
|