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139989

Interleukin-1 receptor antagonist protein (P18510)

Uniprot ID P18510
Protein Name Interleukin-1 receptor antagonist protein
Gene Name IL1RN
Species Homo sapiens (Human)
Basic Information Experiments (0) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b)
Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. .
GO - Molecular function
  • cytokine activity : IBA:GO_Central
  • interleukin-1 receptor antagonist activity : IDA:BHF-UCL
  • interleukin-1 receptor binding : IDA:BHF-UCL
  • interleukin-1 Type I receptor antagonist activity : IDA:BHF-UCL
  • interleukin-1 Type II receptor antagonist activity : IDA:BHF-UCL
  • interleukin-1, Type I receptor binding : IPI:BHF-UCL
  • interleukin-1, Type II receptor binding : IPI:BHF-UCL
GO - Biological process
  • acute-phase response : IDA:BHF-UCL
  • cytokine-mediated signaling pathway : TAS:Reactome
  • fever generation : IBA:GO_Central
  • immune response : NAS:UniProtKB
  • insulin secretion : IEA:Ensembl
  • interleukin-1-mediated signaling pathway : TAS:Reactome
  • lipid metabolic process : IEA:Ensembl
  • negative regulation of heterotypic cell-cell adhesion : IDA:BHF-UCL
  • negative regulation of interleukin-1-mediated signaling pathway : IDA:BHF-UCL
  • response to glucocorticoid : IDA:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.